For over 25 years, researchers in Brazil have been working to see if the placenta-based protein polylaminin can restore function in people with spinal cord injuries. In a news conference this month, researchers announced the results of a successful human trial featuring eight patients. They found the drug, if administered quickly after a spinal cord injury, has the potential to heal damaged spinal cords. Learn more

In a study from the University of Auckland and Chalmers University, an ultra-thin electric implant restored movement and sensory response in rats with serious spinal cord injuries. Over a 12-week trial, paralyzed rats using daily subdural electrical stimulation regained coordinated leg movement and regained sensitivity to touch.

“While gaps remain before human application, this research—backed by successive rat studies and aided by evolving electrical neurostimulation platforms—signals a true turning point. Combining novel electrical implants with AI-guided dosage, wearable power sources, and precision mapping could soon unlock therapies that offer mobility to millions facing spinal cord injuries.” Read more

MIT engineers have discovered how to use gene modification to morph a single skin cell into 10+ neurons, and quickly. Scientists hope to use this discovery to one day treat paralysis:

“After two weeks, the researchers found that many of the neurons had survived and seemed to be forming connections with other brain cells. When grown in a dish, these cells showed measurable electrical activity and calcium signaling, suggesting the ability to communicate with other neurons. The researchers now hope to explore the possibility of implanting these neurons into the spinal cord.” Learn more

For those living with quadriplegia, there is palatable excitement over the ARC System, a device recently passed by the FDA. Created by ONWARD Medical, it uses non-invasive spinal cord stimulation therapy to return hand function. After an overwhelmingly successful clinical trial where 90% of participants experienced improved strength or function in their hands, Time magazine went on to name it one of the best inventions of 2024. ARC will first be available for clinical use in 2025 and soon thereafter will be available for home-use. Learn more

Called spinalNET, this tiny implantable device created at Rice University is hundred times smaller than the width of a piece of hair and has the ability to read the activity of spinal cord neurons in action, which researchers hope will help them identify the severity of spinal cord injuries. With this device, they were able to get “low-noise signals” from hundreds of neurons in the spinal cord, which are typically incredibly difficult to track due to their quick movement. They also hope this technology will one day be used to treat paralysis. Learn more

A clinical trial at the University of Washington found high intensity frequency waves had the ability to help improve hand strength and function in 70% of participants, all whom were quadriplegics. Researchers believe the high intensity waves work by numbing pain fibers that exist within the skin, enabling more signals to reach the spinal cord. Read more

The Mayo Clinic this month released the the findings from phase 1 of a successful spinal cord injury clinical trial that included 10 people with spinal cord injuries. The trial took stem cells from their own fat cells and injected them into their injury sites. Seven out of 10 patients saw an increase in sensation or an increase in strength in various muscles, and 7 of the participants moved up at least one level on the ASIA scale. Learn more

After decades of arduous research by amazing scientists, the future of spinal cord injury research appears to be moving into the exciting direction of brain-computer interface technology. Both China and the US have announced exciting advancements in human trials utilizing this technology, which is a computer chip implanted into the brain that can read brain signals and send them to various parts in the body. To learn more about the NEO System, the brain-interface technology from China click here. And to learn more about Neuralink and its recent success with a quadriplegic undergoing its very first brain implant surgery, click here

NervGen, also known as NVG-291, recently received the FDA’s Fast-Track Designation status to help the drug move quicker through the approval process and human trials have commenced. The researchers behind this drug believe it has the potential to be the first approved treatment to enable neurological recovery. Learn more

Epidural stimulation is the darling of the spinal cord injury research world. The only drawback is that it’s expensive to have a stimulator implanted, which costs approx. $18,000. A new analysis has revealed that external epidural stimulation, which is significantly less expensive, can return leg function as long as three electrodes are used in a specific configuration. Learn more